In addition to dietary intake, malabsorption conditions like celiac disease, atrophic gastritis, and inflammatory bowel diseases, all of autoimmune nature and frequently associated with autoimmune thyroid diseases, must be taken into account when vitamin B12 requirements are evaluated [97,98,99]
Wu Y, Wang D, Wei F, Xiong F, Zhang S, Gong Z, et al
348 A comprehensive multi-proteomic analysis of the lysine lactylome identified lactylation at 872 Kla sites on 284 proteins, predominantly associated with extracellular matrix organization and cholesterol metabolism, suggesting a correlation between lactylation and protein expression in these areas and offering insight into the potential biophysical mechanisms and impact of lactylation on tendon function
The MHRA has approved semaglutide (Wegovy) and liraglutide (Saxenda) specifically for this indication