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Ubiquitinated proteins are detected in oligomeric beta-amyloid (A) plaques and neurofibrillary tangles, and a mutation in the UPS associated gene UBB+1 causes neuronal degeneration, and has been linked to AD (van Leeuwen et al., 1998

Some patients have genetic variants that amplify appetite suppression, while others may require slightly higher doses to feel the same effect

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